The commonly prescribed anti-depressant Zoloft has been found to affect the volume of brain matter in key areas of the brains of depressed and nondepressed patients. This finding was published in the journal Neuropharmacology.
The problem is that Zoloft is administered for various conditions, including OCD, PTSD, bulimia, and many others, and the effects of the changes on patients with those conditions are unknown. Brain structure is crucial for cognitive health, and these are disturbing findings. If you are considering medication for your depression, I suggest neurofeedback training as a safe, side-effect-free approach.
You can read the full study here.